Methandienone, also known as methandrostenolone, is an anabolic steroid and has been one of the most widely used anabolic steroids for years.
It was first synthesized in 1955 by the American doctor John Ziegler. He sold the rights in 1956 to Ciba (Basel), who sold the preparation from 1960 under the trade name Dianabol. 1982 Ciba withdrew Dianabol from the market.
Metandienone is a 17α-alkylated steroid due to its methylation. This alkylation means that metandienone is only subject to a slight first-pass effect, i.e. it can be taken orally. At the same time, it has a lower affinity both for androgen receptors and for sex hormone binding globulin (SHGB). Since only free androgens that are not bound to SHGB are effective, metandienone is significantly more active than testosterone. On the other hand, it aromatizes more easily to the corresponding estrogen.

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