General properties of Trenbolone
The anabolic effect of trenbolone is usually stated in the relevant steroid literature as being 3 to five times the anabolic effect of testosterone. However, some studies also conclude that the anabolic effects of trenbolone and testosterone are roughly equal. So it can only be said with certainty that trenbolone is at least as anabolic as testosterone.
The anabolic effect of trenbolone is based, among other things, on a significant increase in nitrogen storage, which is roughly the same as testosterone. This is another indication that testosterone and trenbolone have similarly powerful anabolic effects.
Another factor that contributes to the anabolic effects of Trenbolone is the fact that Trenbolone can increase IGF-1 levels in muscle tissue by up to 200% and, moreover, the satellite cells of the muscles compared to IGF-1 and FGF (Fibroblast Growth Factor) significantly more sensitive. IGF-1 stimulates the growth of muscle cells and thus has a significant anabolic effect, while FGF stimulates the division of satellite cells and is of crucial importance for the repair of muscle damage. In addition, trenbolone causes a significant increase in the amount of DNA within the muscle cells, which is an important prerequisite for hypertrophy (growth) of the muscle fibers.
With regard to the anabolic effects of trenbolone, it should also be interesting that this active ingredient increases nutrient efficiency due to its nutrient redistribution effect. In practice, this means that a larger proportion of the nutrients supplied are used for building and maintaining muscle tissue and only fewer nutrients end up in the body's fat stores. In addition, trenbolone significantly improves the absorption of dietary minerals.
In addition to its anabolic effect, Trenbolone also has a clear strength-increasing effect, which is based on the fact that this active ingredient promotes the filling of the creatine phosphate stores of the muscle cells, so that more ATP, which is required for muscle contraction, can be produced more quickly.
The androgenic effects of trenbolone
Even though trenbolone is a very widespread active ingredient that has been investigated in countless studies since the early 1960s and has been used in veterinary medicine since the early 1970s, there is still confusion about how strong the Trenbolone really fails androgenic effects.
In the relevant steroid literature one often finds the statement that trenbolone has a strongly pronounced androgenic effect which clearly exceeds the androgenic effect of testosterone and is said to be in the range of the androgenic effect of dihydrotestosterone, the most powerful endogenous androgen. This view is supported by some studies that confirm that trenbolone has an affinity for the androgen receptor that is 3 to 5 times stronger than testosterone.
A more recent study that compared the androgenic effects of trenbolone and testosterone in vivo (on living animals) using the so-called Herschberger assay comes to the conclusion that the androgenic effects of trenbolone in the androgen-sensitive tissue of the prostate are significantly lower than that of testosterone fails. The result of this study also coincides with anecdotal reports from Trenbolone users who report a lower potential for androgen-related side effects compared to testosterone.
The exact causes of the discrepancy between a strong affinity for the androgen receptor on the one hand and a low androgenic effect observed in practice on the other hand can only be speculated at the moment and further studies are required to explain this phenomenon.
In addition to its anabolic and androgenic effects, Trenbolone also has a pronounced anti-catabolic effect, due to which this steroid is, according to observations, valued by many bodybuilders during diet and preparation for competitions. In contrast to most anabolic steroids with anti-catabolic properties, which develop their anti-catabolic effects by competitively occupying the glucocorticoid receptor and thus preventing cortisol from developing its catabolic effect on this receptor, trenbolone has practically no affinity for this receptor.
Nevertheless, trenbolone already significantly reduces the binding of cortisol to the glucocorticoid receptor after a few days, which is probably due to the fact that trenbolone reduces the number of glucocorticoid receptors in the muscles. In addition, trenbolone lowers cortisol secretion by up to 40% and significantly reduces cortisol-induced gene expression.
In practice it can be observed that bodybuilders combine Trenbolone with other anti-catabolic steroids such as testosterone, which unfold their anti-catabolic effect by blocking the glucocorticoid receptors. This leads to a synergistic interaction, since trenbolone reduces the cortisol release and the effect of cortisol, while testosterone prevents the remaining cortisol from developing a catabolic effect on the glucocorticoid receptors.
More muscle hardness?
In addition to its fat burning effects, Trenbolone is also known to promote definition and muscle hardness. In addition to the fact that trenbolone causes practically no estrogen-related water retention, this could also be related to the fact that this active ingredient, like its alpha-17-alkylated counterpart metribolone, acts as an antagonist for the aldosterone receptor and thus blocks it for aldosterone. Aldosterone causes an increased storage of water in the subcutaneous fat tissue, while at the same time it draws water from the muscle tissue. This makes the muscles appear flatter and spongier.
Even if trenbolone can in principle be converted into estrogen by the aromatase enzyme, the rate of conversion is in the range of less than 2% and is therefore practically negligible. At the same time, however, trenbolone has a clear affinity for the progesterone receptor, which, depending on the source, is almost as strong as progesterone itself and can also produce a significant progesterone effect on this receptor.
Areas of application
In practice it can be observed that Trenbolone Enanthate is used both during diet and preparation for competitions as well as during mass building. It can be observed that longer-acting trenbolone esters such as trenbolone enanthate are used more frequently for the purpose of building mass, whereas short-acting trenbolone acetate is preferred over longer-acting trenbolone esters during diet and competition preparation.
The use of trenbolone by endurance athletes can practically not be observed, as this active ingredient seems to have a negative influence on endurance performance for reasons that are not yet known in detail.